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Un metabolito inducido por el ejercicio que suprime la alimentación y la obesidad
Veronica L Li1,2,3,4, Yang He5, Kévin Contrepois6,7,8
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Nature
|June 15, 2022
Resumen
El ejercicio estimula la producción de N-lactoil-fenilalanina (Lac-Phe), un metabolito que suprime el apetito y la obesidad. Esta molécula conservada regula el comportamiento de alimentación y el equilibrio energético sistémico entre especies.
Área de la Ciencia:
- Investigación metabólica
- Fisiología del ejercicio
- Biología molecular
Sus antecedentes:
- El ejercicio ofrece protección contra la obesidad y las enfermedades cardiometabólicas.
- Los mecanismos moleculares precisos detrás de los beneficios metabólicos del ejercicio no se comprenden completamente.
Objetivo del estudio:
- Identificar los mediadores moleculares de los beneficios metabólicos inducidos por el ejercicio.
- Investigar el papel de la N-lactoil-fenilalanina (Lac-Phe) en la regulación del comportamiento alimenticio y el peso corporal.
Principales métodos:
- Investigó la producción de N-lactoil-fenilalanina (Lac-Phe) en respuesta al ejercicio.
- Se utilizaron enfoques farmacológicos y genéticos en ratones obesos inducidos por la dieta para evaluar los efectos de Lac-Phe.
- Los niveles de Lac-Phe medidos en humanos y caballos de carreras después de la actividad física.
Principales resultados:
- El ejercicio estimula la producción de N-lactoil-fenilalanina (Lac-Phe) en varios tipos de células.
- Los aumentos farmacológicos en Lac-Phe redujeron la ingesta de alimentos y la obesidad en ratones.
- La ablación genética de la biosíntesis Lac-Phe condujo a un aumento de la ingesta de alimentos y la obesidad después del ejercicio.
- Se observaron niveles elevados de Lac-Phe en humanos y caballos de carreras después de la actividad física.
Conclusiones:
- La N-lactoil-fenilalanina (Lac-Phe) es un metabolito conservado inducible por el ejercicio que suprime la alimentación y la obesidad.
- Lac-Phe actúa como un efector molecular de la actividad física, influyendo en el equilibrio energético sistémico.
- Este descubrimiento proporciona un nuevo objetivo para el manejo de la obesidad y los trastornos metabólicos.
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