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Los virus entéricos se replican en las glándulas salivales e infectan a través de la saliva
S Ghosh1, M Kumar1, M Santiana1
1Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Nature
|June 29, 2022
Resumen
Los virus entéricos infectan las glándulas salivales, replicándose y diseminándose a través de la saliva. Este descubrimiento revela una nueva ruta de transmisión más allá de la fecal-oral, que tiene un impacto en las estrategias de transmisión madre-bebé y saneamiento.
Área de la Ciencia:
- Virología
- Gastroenterología
- Inmunología
Sus antecedentes:
- Los virus entéricos se propagan tradicionalmente por la vía fecal-oral.
- Las glándulas salivales no se consideraron un sitio primario para la replicación del virus entérico.
- Algunos virus, como la rabia, infectan a los SG y se transmiten a través de la saliva.
Objetivo del estudio:
- Investigar si los virus entéricos infectan y se replican en las glándulas salivales.
- Identificar nuevas vías de transmisión para los virus entéricos.
- Explorar las implicaciones de la infección de las glándulas salivales para la propagación y el control de enfermedades.
Principales métodos:
- Infección de esferoides y líneas celulares derivadas de SG con virus entéricos.
- Cuantificación de los títulos virales en los SG y los intestinos.
- Análisis de la liberación viral en la saliva.
- Investigación de la transmisión del bebé a la madre a través de la saliva y la leche.
Principales resultados:
- Los virus entéricos infectan de manera productiva y persistente las glándulas salivales.
- Los títulos virales en SG fueron comparables a los títulos intestinales.
- Los virus entéricos se liberan en la saliva, estableciendo una nueva ruta de transmisión.
- La saliva del bebé puede transmitir virus entéricos a las glándulas mamarias de las madres, sin pasar por el eje intestino-mamario.
Conclusiones:
- Las glándulas salivales sirven como un sitio de replicación importante para los virus entéricos.
- La saliva representa una ruta nueva e importante para la transmisión del virus entérico.
- Los hallazgos requieren estrategias de saneamiento y prevención revisadas para mitigar la propagación viral a través de la saliva.
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