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Falso positivo en la prueba de antígeno criptocócico y absceso prevertebral cervical
JAMA
|October 27, 1978
Resumen
Una prueba de antígeno criptocócico falso positivo en el líquido cefalorraquídeo condujo a un tratamiento innecesario con anfotericina B. Esto pone de relieve la importancia de confirmar los resultados de laboratorio para garantizar un diagnóstico preciso y la atención oportuna del paciente.
Área de la Ciencia:
- Microbiología Médica Microbiología médica.
- Enfermedades infecciosas Enfermedades infecciosas.
- Diagnóstico Clínico El diagnóstico clínico.
Sus antecedentes:
- Las pruebas de diagnóstico con resultados falsos positivos pueden conducir a un tratamiento médico inadecuado.
- La prueba del antígeno criptocócico es crucial para el diagnóstico de infecciones criptocócicas.
Objetivo del estudio:
- Para reportar un caso de una prueba de aglutinación de látex de antígeno criptocócico falso positivo.
- Para enfatizar las implicaciones clínicas de los resultados diagnósticos erróneos.
Principales métodos:
- Informe de caso de un paciente con absceso prevertebral cervical y osteomielitis vertebral.
- Utilizó un kit de prueba comercial de aglutinación de látex para la detección del antígeno criptocócico del líquido cefalorraquídeo (LCR).
- Reevaluación del CSF en un laboratorio de referencia.
Principales resultados:
- Las pruebas iniciales de LCR mostraron un título positivo de antígeno criptocócico (1:32).
- Las pruebas posteriores en un laboratorio de referencia no revelaron ningún antígeno criptocócico en el LCR.
- El paciente tenía una infección causada por Klebsiella pneumoniae.
Conclusiones:
- Se produjo una prueba de aglutinación de látex de falso positivo para el antígeno criptocócico.
- Este resultado falso positivo condujo a una terapia innecesaria con anfotericina B.
- El retraso en el diagnóstico y tratamiento adecuados para la infección real por Klebsiella pneumoniae.
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