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Los flavivirus secuestran la microbiota huésped para facilitar su transmisión
Lejla Gul1, Tamas Korcsmaros2, Neil Hall3
1Earlham Institute, Norwich, UK; Imperial College London, Department of Metabolism, Reproduction and Development, London, UK.
Cell
|July 8, 2022
Resumen
Los flavivirus como el dengue y el Zika manipulan el microbioma de la piel para aumentar la atracción y propagación de los mosquitos. La vitamina A puede contrarrestar estos efectos, reduciendo la transmisión viral.
Área de la Ciencia:
- Virología
- Investigación del microbioma
- Enfermedades infecciosas
Sus antecedentes:
- Los flavivirus, incluidos el dengue y el zika, representan una amenaza significativa para la salud mundial.
- Los mosquitos sirven como vectores primarios para la transmisión de estos virus.
- La comprensión de las interacciones huésped-patógeno es crucial para el control de la enfermedad.
Objetivo del estudio:
- Para investigar cómo los flavivirus alteran el microbioma de la piel del huésped.
- Para determinar el impacto de estas alteraciones en el comportamiento del vector y la transmisión viral.
- Identificar posibles estrategias terapéuticas para mitigar la propagación del virus.
Principales métodos:
- Análisis de la composición del microbioma cutáneo en huéspedes infectados y de control.
- Pruebas de comportamiento para evaluar la atracción de los mosquitos hacia los huéspedes infectados.
- Investigar el papel de los metabolitos microbianos específicos y los factores del huésped.
Principales resultados:
- La infección por flavivirus remodela significativamente el microbioma de la piel.
- La composición alterada del microbioma aumenta la atracción de los mosquitos hacia los individuos infectados.
- Se descubrió que la suplementación con vitamina A revierte los cambios en el microbioma y reduce la atracción de vectores.
Conclusiones:
- Los flavivirus manipulan activamente el microbioma de la piel para facilitar la transmisión.
- Dirigirse al microbioma de la piel, potencialmente con vitamina A, ofrece una nueva estrategia para controlar la propagación del flavivirus.
- Esta investigación pone de relieve la intrincada relación entre la inmunidad del huésped, el microbioma y la dinámica de las enfermedades transmitidas por vectores.
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