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Physiology of the Gastrointestinal System II: Digestion and Absorption01:22

Physiology of the Gastrointestinal System II: Digestion and Absorption

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The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
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Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Major Organs of the Digestive System01:19

Major Organs of the Digestive System

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The digestive system is responsible for the ingestion of food, secretion of enzymes, mixing and digesting food, absorption of the nutrients and defecation. The human digestive system consists of two major parts: the gastrointestinal tract and the accessory digestive organs.
Gastrointestinal tract:
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Physiology of the Gastrointestinal System III: Elimination01:26

Physiology of the Gastrointestinal System III: Elimination

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The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
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Video Experimental Relacionado

Updated: Sep 4, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

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Más allá de las tripas

Irina Leonardi1

  • 1Immunai, New York, NY, USA.

Science (New York, N.Y.)
|July 20, 2022
PubMed
Resumen

El estudio revela que los hongos, conocidos como microbiota, influyen significativamente en el huésped.

Área de la Ciencia:

  • Biología fúngica
  • Inmunología
  • La neurociencia

Sus antecedentes:

  • El cuerpo humano alberga una compleja comunidad de hongos, llamada microbiota.
  • Las interacciones de hongos con el sistema inmunológico del huésped son cada vez más reconocidas.
  • El impacto de la microbiota en el comportamiento del huésped sigue siendo en gran medida inexplorado.

Objetivo del estudio:

  • Para investigar el papel de la microbiota en la modulación de la inmunidad del huésped.
  • Para explorar la influencia de la microbiota en el comportamiento del huésped.

Principales métodos:

  • Utilización de modelos animales para estudiar las interacciones hongo-huésped.
  • El uso de ensayos inmunológicos para evaluar las respuestas inmunológicas.
  • Pruebas de comportamiento para cuantificar cambios en las acciones del huésped.

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Last Updated: Sep 4, 2025

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Principales resultados:

  • La composición de microbiota afecta significativamente la actividad de las células inmunes.
  • Se descubrió que ciertas especies de hongos alteran las vías inmunológicas clave.
  • La presencia de hongos se correlacionó con cambios medibles en los patrones de comportamiento del huésped.

Conclusiones:

  • La microbiota juega un papel crucial en la regulación de la inmunidad del huésped.
  • Las comunidades de hongos pueden influir en el comportamiento del huésped, lo que sugiere un vínculo entre el eje intestino-cerebro y la presencia de hongos.