Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Stem Cell Niche01:26

Stem Cell Niche

5.2K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.2K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.8K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.8K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.8K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.8K
Stem Cell Culture01:17

Stem Cell Culture

5.3K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Deciphering Facioscapulohumeral Dystrophy in the clinical trials era: where are we now?

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology·2025
Same author

SMCHD1 activates the expression of genes required for the expansion of human myoblasts.

Nucleic acids research·2024
Same author

Long non-coding RNAs and their role in muscle regeneration.

Current topics in developmental biology·2024
Same author

Meeting report: The 2023 FSHD International Research Congress.

Neuromuscular disorders : NMD·2023
Same author

DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia.

Science advances·2023
Same author

MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy.

Cell reports·2023
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Sep 2, 2025

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

12.3K

Un nicho regenerativo para las células madre

Davide Gabellini1

  • 1Division of Genetics and Cell Biology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milano, Italy.

Science (New York, N.Y.)
|August 4, 2022
PubMed
Resumen
Este resumen es generado por máquina.

La producción de ácido hialurónico es clave para la regeneración de las células madre musculares después de una lesión. Esta molécula de señalización ayuda a activar los procesos de reparación, promoviendo la recuperación en el tejido muscular dañado.

Más Videos Relacionados

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

4.5K
Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.0K

Videos de Experimentos Relacionados

Last Updated: Sep 2, 2025

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

12.3K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

4.5K
Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.0K

Área de la Ciencia:

  • La bioquímica
  • La Medicina Regenerativa
  • Biología muscular

Sus antecedentes:

  • Las lesiones musculares desencadenan respuestas celulares complejas.
  • La activación de las células madre es crucial para la reparación del tejido.
  • El papel de las biomoléculas específicas en la regeneración muscular es un área activa de investigación.

Objetivo del estudio:

  • Investigar el papel del ácido hialurónico en la activación de las células madre musculares después de una lesión.
  • Para aclarar las vías de señalización regenerativa iniciadas por el ácido hialurónico.

Principales métodos:

  • Se utilizaron modelos in vitro de células madre musculares.
  • Análisis de los niveles de producción de ácido hialurónico después de una lesión simulada.
  • Evento de señalización posterior evaluado en células madre musculares.

Principales resultados:

  • La producción de ácido hialurónico aumentó significativamente después de la lesión muscular.
  • El tratamiento exógeno con ácido hialurónico aumentó la proliferación y diferenciación de células madre musculares.
  • Las vías de señalización regenerativa clave fueron activadas por el ácido hialurónico.

Conclusiones:

  • El ácido hialurónico juega un papel crítico en la orquestación de la regeneración mediada por células madre musculares.
  • La orientación de las vías del ácido hialurónico puede ofrecer estrategias terapéuticas para la reparación muscular.