Terapia y profilaxis del paludismo
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Updated: Aug 17, 2026
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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
Published on: July 17, 2014
JAMA
|November 17, 1978
Resumen
Los médicos deben estar preparados para tratar la malaria y proporcionar medicamentos de viaje. La cloroquina se recomienda para la mayoría de los casos de malaria, pero se prefiere la quinina para las infecciones graves por Plasmodium falciparum, sin una profilaxis perfecta para las cepas resistentes.
Área de la Ciencia:
- Ciencias Médicas Ciencias Médicas.
- Enfermedades infecciosas Enfermedades infecciosas.
- La Medicina Tropical es una medicina tropical.
Sus antecedentes:
- La malaria sigue siendo un importante problema de salud mundial, especialmente para los viajeros.
- Los médicos requieren una guía actualizada sobre el tratamiento y la profilaxis de la malaria.
Objetivo del estudio:
- Para esbozar las recomendaciones actuales para la profilaxis y el tratamiento de la malaria.
- Para resaltar los desafíos en el manejo de cepas específicas de malaria.
Principales métodos:
- Revisión de las directrices establecidas para el tratamiento de la malaria.
- Análisis de la eficacia del fármaco para diferentes especies de Plasmodium y gravedad de la infección.
Principales resultados:
- El clorhidrato de cloroquina es el principal agente para la malaria leve y la profilaxis general.
- La quinina es el tratamiento preferido para las infecciones graves por Plasmodium falciparum.
- La primaquina es necesaria para Plasmodium vivax y Plasmodium ovale, lo que requiere pruebas de glucosa-6-fosfato deshidrogenasa.
- No existe una profilaxis completamente efectiva en los EE.UU. para el Plasmodium falciparum resistente a la cloroquina.
Conclusiones:
- Los médicos deben estar preparados para el tratamiento y la profilaxis de la malaria.
- Las recomendaciones actuales favorecen la cloroquina y la quinina, con consideraciones específicas para la primaquina y las cepas resistentes.
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