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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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El orgullo de las STEM en todo el mundo

Juno Obedin-Maliver, Erinma Ochu, Franklin Zhong

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    Este resumen es generado por máquina.

    Los científicos LGBTQ+ comparten cómo su identidad impacta sus experiencias en Ciencia, Tecnología, Ingeniería y Matemáticas (STEM). Seis investigadores discuten cómo su experiencia, enfoque, instituciones y ubicación influyen en sus viajes científicos, promoviendo la inclusión.

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    Área de la Ciencia:

    • Ciencia, Tecnología, Ingeniería y Matemáticas (STEM).

    Sus antecedentes:

    • Los científicos LGBTQ+ se enfrentan a desafíos y experiencias únicas dentro de STEM.
    • Comprender estas experiencias es crucial para fomentar la inclusión.

    Objetivo del estudio:

    • Para explorar cómo la identidad LGBTQ + da forma a las experiencias de los científicos en STEM.
    • Para resaltar las diversas perspectivas de los investigadores a nivel mundial.

    Principales métodos:

    • Recopilación de datos cualitativos mediante entrevistas o cuentas personales.
    • Centrarse en las narrativas individuales de seis científicos LGBTQ+.

    Principales resultados:

    • Las experiencias están influenciadas por una combinación de identidad personal, disciplina científica, entorno institucional y ubicación geográfica.
    • El viaje de cada científico es único, moldeado por factores que se cruzan.

    Conclusiones:

    • Diversos factores dan forma a las experiencias de los científicos LGBTQ+ en STEM.
    • Compartir estas perspectivas es vital para avanzar en la inclusión en las comunidades científicas.