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Emisión luminosa, modular y conmutable de infrarrojo cercano II de complejos diradicaloides compactos basados en

Lauren E McNamara¹, Jan-Niklas Boyn¹, Christopher Melnychuk¹

¹Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.

Journal of the American Chemical Society

|August 29, 2022

Resumen

Los investigadores desarrollaron nuevos complejos fluorescentes diradicaloides compactos para imágenes de infrarrojo cercano (NIR) II. Estas moléculas estables y brillantes ofrecen propiedades ajustables y sensibilidad electroquímica, superando a los tintes NIR II existentes.

Área de la Ciencia:

Ciencias de los materiales
Química
Biotecnología

Sus antecedentes:

Las moléculas emisoras de infrarrojo cercano (NIR) son cruciales para la detección y la imagen biológica.
Los tintes NIR existentes a menudo sufren de baja estabilidad, solubilidad y atunizabilidad debido a los grandes sistemas conjugados.

Objetivo del estudio:

Informar sobre una nueva clase de complejos diradicaloides fluorescentes compactos y sintonizables.
Para abordar las limitaciones de los tintes NIR actuales para aplicaciones avanzadas de imágenes.

Principales métodos:

Síntesis de nuevos complejos diradicaloides con variedades π comprimidas.
Caracterización de las propiedades fotofísicas, incluida la emisión en la región NIR II (1000-1700 nm).
Evaluación de la estabilidad (aire, agua, luz, temperatura) y de la sensibilidad electroquímica.

Principales resultados:

Desarrolló complejos diradicaloides fluorescentes estables, compactos y sintonizables.
Se obtiene una emisión brillante a ~ 1200 nm en la región NIR II, significativamente más brillante que los tintes comerciales como IR 26.
Se ha demostrado un cambio eficiente de fluorescencia tras la adición de agentes redox, lo que indica sensibilidad electroquímica.

Conclusiones:

Los nuevos complejos diradicaloides exhiben un brillo, estabilidad y modularidad superiores en comparación con los emisores NIR II existentes.
Estas propiedades las convierten en muy prometedoras para el desarrollo de nuevas tecnologías de detección e imágenes biológicas profundas NIR II.

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