Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chemical Synapses01:26

Chemical Synapses

9.0K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
9.0K
The Neuromuscular Junction01:19

The Neuromuscular Junction

10.8K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
10.8K
Electrical Synapses01:28

Electrical Synapses

8.7K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
8.7K
The Synapse02:47

The Synapse

126.8K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
126.8K
Neural Circuits01:25

Neural Circuits

1.5K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.5K
Synaptic Signaling01:09

Synaptic Signaling

5.7K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.7K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Context dependency in cancer neuroscience.

Cancer cell·2026
Same author

Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation.

Cell·2026
Same author

Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation.

Cell·2026
Same author

TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine.

Science advances·2026
Same author

A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control.

Neuron·2026
Same author

Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.

Cell·2026

Video Experimental Relacionado

Updated: Aug 30, 2025

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

6.2K

Una sinapsis ciliar para la neuromodulación de "cortocircuito"

David J Simon1, Joshua Levitz1

  • 1Weill Cornell Medical College, Department of Biochemistry, New York, NY 10024, USA.

Cell
|September 2, 2022
PubMed
Resumen

Los investigadores descubrieron una nueva sinapsis que vincula los axones serotoninérgicos con los cilios primarios en las neuronas del hipocampo. Este hallazgo arroja luz sobre el papel de los cilios primarios en la señalización neuromoduladora dentro del cerebro.

Más Videos Relacionados

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
10:24

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

17.4K
In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
10:31

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Published on: August 18, 2020

5.6K

Videos de Experimentos Relacionados

Last Updated: Aug 30, 2025

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

6.2K
Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
10:24

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

17.4K
In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
10:31

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Published on: August 18, 2020

5.6K

Área de la Ciencia:

  • La neurociencia
  • Biología celular
  • Transmisión sináptica

Sus antecedentes:

  • Los cilios primarios son omnipresentes en las neuronas, sin embargo, su función en la neuromodulación sigue siendo en gran medida inexplorada.
  • Comprender el papel de los cilios primarios en la comunicación neuronal es crucial para descifrar las funciones cerebrales complejas.

Objetivo del estudio:

  • Investigar la contribución de los cilios primarios a la señalización neuromoduladora.
  • Identificar nuevas estructuras sinápticas involucradas en la interacción entre los axones serotoninérgicos y las neuronas del hipocampo.

Principales métodos:

  • Utilizó microscopía electrónica avanzada para imágenes de alta resolución de estructuras neuronales.
  • Se emplean técnicas de imagen fluorescente para visualizar componentes y actividad sináptica.
  • Centrado en el sistema serotoninérgico y los cilios primarios en las neuronas del hipocampo.

Principales resultados:

  • Reveló un tipo de sinapsis previamente desconocido.
  • Transmisión química directa demostrada entre los axones serotoninérgicos y los cilios primarios de las neuronas del hipocampo.
  • Proporcionó evidencia ultrastructural para esta nueva conexión sináptica.

Conclusiones:

  • El cilium primario es un compartimiento funcional para la señalización neuromoduladora.
  • Se ha identificado una nueva vía para la señalización de la serotonina a las neuronas del hipocampo a través de los cilios primarios.
  • Este descubrimiento abre nuevas vías para comprender la modulación del circuito neuronal y los posibles objetivos terapéuticos.