Videos de Conceptos Relacionados
00:46Feedback Inhibition
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
01:43Proofreading
Overview
01:01Feedback Loops
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
01:31Proofreading
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Errors During Replication are Corrected by the DNA Polymerase Enzyme
01:17Hypothesis: Accept or Fail to Reject?
The outcome of any hypothesis testing leads to rejecting or not rejecting the null hypothesis. This decision is taken based on the analysis of the data, an appropriate test statistic, an appropriate confidence level, the critical values, and P-values. However, when the evidence suggests that the null hypothesis cannot be rejected, is it right to say, 'Accept' the null hypothesis?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null hypothesis and 'fail to...
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null hypothesis and 'fail to...
01:23Journal Bearings
Journal bearings are mechanical components that support and provide lateral stability to rotating shafts and axles. They are crucial in reducing friction, wear, and vibration in machinery such as engines, turbines, and pumps. The principle behind journal bearings is forming a thin lubricant film between the bearing surface and the rotating shaft, which minimizes direct contact and reduces frictional forces.
To better understand the concept of journal bearings, consider a rope winch with dry or...
To better understand the concept of journal bearings, consider a rope winch with dry or...
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La revista declara el fin de la aceptación o rechazo de trabajos
Science (New York, N.Y.)
|October 27, 2022
Resumen
eLife ahora cobrará una tarifa de $ 2000 para la revisión por pares de las presentaciones seleccionadas. Los trabajos aceptados y sus críticas se harán accesibles al público.
Área de la Ciencia:
- Publicaciones académicas
- Comunicaciones científicas
- Iniciativas de ciencia abierta
Sus antecedentes:
- Los modelos tradicionales de publicación académica a menudo implican largos procesos de revisión y acceso restringido a los hallazgos de la investigación.
- El aumento de los costes asociados a la publicación puede ser un obstáculo para los investigadores y las instituciones.
- Existe una creciente demanda de un discurso científico más transparente y accesible.
