Video Experimental Relacionado

Updated: Aug 23, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

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El efecto de polarización del átomo de selenio determina el reconocimiento específico de TrxR de los metalófaros

Mingkai Chen1, Wenqiang Cao1, Junping Wang1

  • 1Department of Chemistry, and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.

Journal of the American Chemical Society
|November 1, 2022
PubMed
Resumen

Los científicos desarrollaron una nueva estrategia para inhibir selectivamente la tiorredoxina reductasa (TrxR) mediante la creación de un centro de selenio electrófilo. Este enfoque mejora la eficacia y la selectividad de los medicamentos contra el cáncer, ofreciendo una nueva ruta para la quimioterapia contra el cáncer.

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