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Updated: Aug 20, 2025

Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates
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Bases estructurales para la interacción adversa grave de sofosbuvir y amiodarona en los canales Cav de tipo L

Xia Yao1, Shuai Gao1, Jixin Wang2

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Cell
|November 23, 2022
PubMed
Resumen

Se investigaron las interacciones farmacológicas fatales entre el sofosbuvir antiviral y la amiodarona antiarrítmica. Sofosbuvir se une dentro del canal de calcio ocupado por la amiodarona, bloqueando el flujo de iones y causando efectos peligrosos en el ritmo cardíaco.

Palabras clave:
Ca ((v) 1) yCa ((v) 1.3)Canales de Ca (v) tipo Lel amiodaroneCrio-EMseguridad de las drogasInteracciones entre fármacosbradicardia severaSofosbuvir y sus derivadosCanales de calcio regulados por tensión

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