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Las bacterias de ingeniería como terapias interactivas contra el cáncer
Candice R Gurbatri1, Nicholas Arpaia2,3, Tal Danino1,3,4
1Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Science (New York, N.Y.)
|November 24, 2022
Resumen
Las bacterias diseñadas se pueden programar utilizando biología sintética para administrar terapias contra el cáncer directamente a los tumores. Este enfoque mejora la seguridad y la eficacia del tratamiento mediante el control de la actividad bacteriana y la entrega de la carga terapéutica dentro del microambiente tumoral.
Área de la Ciencia:
- Biología sintética
- Terapéutico microbiano
- Investigación sobre el cáncer
Sus antecedentes:
- Los microbios son cada vez más reconocidos como colonizadores de tumores.
- Las bacterias pueden ser diseñadas como sistemas de entrega específicos del tumor.
- Las bacterias diseñadas pueden modular el microambiente tumoral a través de la inmunogenicidad inherente y la producción local de carga útil.
Objetivo del estudio:
- Revisar los circuitos genéticos para mejorar el control espacial y temporal de las bacterias terapéuticas.
- Describir la ingeniería de las interacciones entre bacterias, células tumorales y células inmunes.
- Explorar la progresión hacia la combinación de bacterias con otras modalidades terapéuticas.
Principales métodos:
- Revisión de los circuitos genéticos para el control de las bacterias terapéuticas.
- Ingeniería de las interacciones entre bacterias, células tumorales y células inmunes.
- Desarrollo de estrategias de combinación para terapias bacterianas.
Principales resultados:
- Los circuitos genéticos ofrecen un mejor control espacial y temporal de las bacterias terapéuticas.
- Las interacciones de ingeniería mejoran la seguridad y la eficacia de las terapias bacterianas.
- La combinación de agentes bacterianos con otras modalidades es prometedora.
Conclusiones:
- La biología sintética permite el desarrollo de medicamentos programables basados en bacterias.
- Las interacciones de ingeniería son clave para avanzar en las terapias bacterianas contra el cáncer.
- El campo se está moviendo hacia un concepto de medicamentos programables a través de la biología sintética.
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