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Las células dendríticas dirigen las respuestas inmunes anti-tumorales circadianas

Chen Wang1, Coline Barnoud1, Mara Cenerenti1,2

  • 1Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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|December 5, 2022
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Resumen

El crecimiento del tumor está influenciado por la hora del día en que comienza. Los ritmos circadianos en las células inmunes como las células dendríticas y las células T CD8 + controlan el volumen del melanoma, lo que afecta la efectividad de la inmunoterapia contra el cáncer.

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Área de la Ciencia:

  • Inmunología
  • Cronología
  • Investigación del cáncer

Sus antecedentes:

  • La inmunovigilancia del cáncer es una defensa natural contra el desarrollo de tumores.
  • No se comprende bien la fluctuación diaria en la eficacia de la inmunovigilancia del cáncer.

Objetivo del estudio:

  • Investigar si la hora del día influye en la eficacia de la inmunovigilancia del cáncer.
  • Explorar el papel de los ritmos circadianos en las células inmunes que controlan el crecimiento tumoral.

Principales métodos:

  • Se utilizaron modelos de cáncer de ratón, incluidos los ratones con inmunodeficiencia.
  • Se evaluó el impacto del momento del injerto tumoral en el tamaño del tumor.
  • Se investigó la función de las células dendríticas (CD) y las células T CD8+ en la actividad antitumoral circadiana.

Principales resultados:

  • El momento del injerto tumoral afecta significativamente el tamaño posterior del tumor.
  • Las células dendríticas y las células T CD8+ exhiben funciones circadianas que suprimen el crecimiento del melanoma.
  • El tráfico rítmico de CC y la expresión de CD80 regulan las respuestas de las células T CD8+.

Conclusiones:

  • Los ritmos circadianos en los componentes inmunes son cruciales para controlar el tamaño del tumor.
  • La sincronización de la inmunoterapia contra el cáncer con las funciones circadianas continuas mejora la eficacia del tratamiento.
  • Estos hallazgos sugieren posibles aplicaciones terapéuticas de los tratamientos de cáncer basados en el ritmo circadiano en humanos.