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Updated: Aug 14, 2025

Using a Knee Arthrometer to Evaluate Tissue-specific Contributions to Knee Flexion Contracture in the Rat
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La excesiva mecanotransducción en las neuronas sensoriales causa contracturas articulares

Shang Ma1, Adrienne E Dubin1, Luis O Romero2,3

  • 1Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|January 12, 2023
PubMed
Resumen

Las mutaciones de ganancia de función en PIEZO2 causan artrogriposis distal tipo 5 (DA5). La mecanosensibilidad hiperactiva en las neuronas sensoriales interrumpe el desarrollo musculoesquelético, pero los tratamientos dirigidos a PIEZO2 son prometedores.

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