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Las neuronas táctiles subyacentes al tacto dopaminérgico y a la receptividad sexual

Leah J Elias¹, Isabella K Succi², Melanie D Schaffler¹

¹Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.

|January 24, 2023

Resumen

Las neuronas sensoriales específicas (linaje Mrgprb4) son cruciales para la receptividad sexual en ratones hembras. La activación de estas neuronas induce sensaciones gratificantes y posturas de apareamiento, destacando su papel en el contacto social.

Área de la Ciencia:

La neurociencia
Biología sensorial
Ciencias del comportamiento

Sus antecedentes:

El tacto placentero es vital para el comportamiento social, especialmente los encuentros sexuales.
Las neuronas sensoriales específicas responsables de la transducción de las señales de contacto sexual siguen sin identificarse.

Objetivo del estudio:

Para investigar el papel de las neuronas sensoriales del linaje Mrgprb4 en el comportamiento sexual y la recompensa.
Para determinar si estas neuronas son suficientes para inducir la receptividad sexual y los comportamientos asociados.

Principales métodos:

Utilizó el etiquetado genético para identificar las neuronas del linaje Mrgprb4 en ratones.
Empleó estimulación optogenética para activar estas neuronas.
Respuestas conductuales evaluadas, incluida la preferencia por el lugar condicionado y la postura copulatoria.
Se midió la liberación de dopamina en el núcleo accumbens.

Principales resultados:

La activación de las neuronas del linaje Mrgprb4 indujo la preferencia condicionada por el lugar y la postura lordótica, incluso con la estimulación a través de la piel de la espalda.
La ausencia de estas neuronas abolió los efectos gratificantes de las monturas masculinas y condujo a la agresión.
La liberación de dopamina en el núcleo accumbens disminuyó cuando las neuronas del linaje Mrgprb4 estaban ausentes.

Conclusiones:

Las neuronas del linaje Mrgprb4 son esenciales para la receptividad sexual y codifican los aspectos gratificantes del contacto social.
Estas neuronas inician un circuito crítico de la piel al cerebro para procesar estímulos sexuales gratificantes.

Palabras clave:

Optogenética periférica el placer recompensas la médula espinal El toque.

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