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Updated: Aug 11, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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El reciclaje de H2A-H2B modificado proporciona memoria a corto plazo de los estados de la cromatina

Valentin Flury1, Nazaret Reverón-Gómez1, Nicolas Alcaraz1

  • 1Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark.

Cell
|February 7, 2023
PubMed
Resumen

Las modificaciones de la histona parental H2A-H2B se reciclan con precisión durante la replicación del ADN, asegurando la herencia epigenética. Este proceso guía la restauración de los estados de cromatina, manteniendo la regulación del genoma y la identidad celular.

Palabras clave:
Replicación del ADNH2A y sus derivadosH2A.ZH2B y sus derivadosCromatina y sus derivadosHistona PTM conversación cruzadaReciclaje de histonasel policombradoModificaciones posteriores a la traducciónubiquitinación

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