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Las neuronas límbicas hiperexcitadas representan la saciedad sexual y reducen la motivación de apareamiento

Xiaojuan Zhou¹, Ang Li^1,2, Xue Mi¹

¹Chinese Institute for Brain Research, Beijing 102206, China.

Science (New York, N.Y.)

|February 9, 2023

Resumen

Las experiencias sexuales alteran los circuitos cerebrales, causando cambios duraderos en el impulso de apareamiento. La eyaculación activa neuronas específicas en el núcleo del lecho de la estrías terminales (BNST), lo que lleva a la saciedad sexual y a la reducción de la motivación.

Área de la Ciencia:

La neurociencia
Biología del comportamiento
Endocrinología

Sus antecedentes:

Las experiencias sexuales transitorias pueden inducir cambios de comportamiento a largo plazo.
Los mecanismos neuronales subyacentes de estos efectos persistentes siguen siendo en gran medida desconocidos.

Objetivo del estudio:

Investigar la codificación neuronal de los cambios de comportamiento dependientes de la experiencia sexual.
Identificar poblaciones neuronales específicas y mecanismos moleculares involucrados en la saciedad sexual y el impulso de apareamiento.

Principales métodos:

Se utilizaron modelos de roedores para estudiar los efectos de la eyaculación en la actividad neuronal.
Técnicas empleadas que incluyen activación / inhibición neuronal, electrofisiología y ensayos conductuales.
Investigó el papel de las neuronas que expresan el receptor de estrógeno 2 (Esr2) en el núcleo del lecho de la estria terminal (BNST).

Principales resultados:

La eyaculación activó selectivamente las neuronas BNST que expresan el receptor de estrógeno 2 (BNSTEsr2).
Esta activación condujo a una disminución persistente en el umbral de disparo neuronal y indujo la saciedad sexual.
La inhibición de las neuronas BNSTEsr2 hiperexcitadas restauró rápidamente el comportamiento de apareamiento en ratones saciados.
En los machos, la hiperexcitabilidad de BNSTEsr2 redujo la motivación de apareamiento, mediada en parte por corrientes de nucleótidos cíclicos activados por hiperpolarización (HCN).

Conclusiones:

Las neuronas BNSTEsr2 codifican no solo acciones de apareamiento sino también un estado persistente de saciedad sexual.
Las alteraciones en los canales iónicos neuronales contribuyen a los cambios a largo plazo en el impulso de apareamiento después de la experiencia sexual.
Estos hallazgos proporcionan información sobre la base neuronal de la plasticidad del comportamiento después de los encuentros sexuales.

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