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La base del desarrollo de la formación y variación del patrón de huellas dactilares
James D Glover1, Zoe R Sudderick1, Barbara Bo-Ju Shih1
1The Roslin Institute and R(D)SVS, University of Edinburgh, Edinburgh EH25 9RG, UK.
Cell
|February 10, 2023
Resumen
Las huellas dactilares humanas se desarrollan a partir de un programa parcial de folículos pilosos, no reclutando células mesenquimales. Un sistema de difusión de reacción de Turing que involucra la señalización EDAR, WNT y BMP crea patrones de huellas dactilares únicos a través del crecimiento epitelial en forma de onda.
Área de la Ciencia:
- Biología del desarrollo
- Dermatología
- Formación del patrón
Sus antecedentes:
- Las huellas dactilares son patrones únicos de la piel formados prenatalmente.
- Los mecanismos moleculares y celulares que impulsan la formación de huellas digitales siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Aclarar los mecanismos de desarrollo subyacentes a la formación de la cresta de huellas dactilares y la generación de patrones.
- Identificar las vías de señalización clave involucradas en el establecimiento de patrones de huellas dactilares.
Principales métodos:
- Análisis de las crestas de huellas dactilares como programas de desarrollo de folículos pilosos truncados.
- Modelado de la formación de patrones de huellas digitales utilizando un sistema de difusión de reacción de Turing.
- Investigando las funciones de las vías de señalización EDAR, WNT y BMP.
Principales resultados:
- Las crestas de huellas digitales se desarrollan a partir de estructuras epiteliales con un programa de folículo piloso detenido, sin reclutamiento de condensado mesenquimal.
- Un sistema de difusión de reacción de Turing, impulsado por la señalización EDAR, WNT y BMP, establece el patrón espacial de las crestas de huellas dactilares.
- La formación de patrones implica ondas de proliferación epitelial que se originan en sitios distintos, y su interacción determina el tipo de patrón final.
Conclusiones:
- Los patrones de huellas dactilares surgen de un proceso dinámico de crecimiento epitelial regulado por vías de señalización específicas.
- La interacción de la transmisión de señales y la propagación de ondas explica la diversidad y la singularidad de las huellas dactilares humanas.
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