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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
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Repensar la terapia hormonal en la menopausia: ¿Para quién, qué, cuándo y por cuánto tiempo?
Leslie Cho1, Andrew M Kaunitz2, Stephanie S Faubion3
1Cleveland Clinic, OH (L.C.).
Circulation
|February 13, 2023
Resumen
Se recomienda la terapia hormonal menopáusica para aliviar los síntomas. Los hallazgos recientes aclaran los riesgos cardiovasculares, orientando la selección y formulación de pacientes más seguros para mujeres con riesgo de enfermedad cardíaca.
Área de la Ciencia:
- Medicina cardiovascular
- Salud de las mujeres
- Endocrinología
Sus antecedentes:
- Las preocupaciones anteriores sobre el riesgo cardiovascular con la terapia hormonal combinada (HT) condujeron a una disminución del uso.
- La investigación reciente ha refinado la comprensión del impacto cardiovascular de HT basado en el tiempo, la ruta y los factores del paciente.
- Las principales sociedades médicas ahora recomiendan la terapia hormonal para controlar los síntomas de la menopausia.
Objetivo del estudio:
- Proporcionar una guía actualizada sobre el uso de la terapia hormonal en la menopausia.
- Centrarse en la selección de pacientes y la formulación para mujeres con riesgo de enfermedad cardiovascular (ECV).
- Para atender las necesidades de las mujeres sintomáticas que experimentan síntomas de la menopausia y riesgo de ECV.
Principales métodos:
- Revisión de la literatura científica actual sobre la terapia hormonal y las enfermedades cardiovasculares.
- Análisis de los datos sobre el momento de inicio, la vía de administración y la formulación de HT.
- Recomendaciones basadas en el consenso elaboradas por un comité multidisciplinario de expertos.
Principales resultados:
- La relación entre la HT, el momento del uso y el riesgo cardiovascular es compleja e individualizada.
- Las formulaciones específicas de HT y las vías de administración pueden tener efectos diferenciales en los resultados cardiovasculares.
- Se puede considerar con seguridad la administración de HT en mujeres menopáusicas sintomáticas seleccionadas, especialmente cuando se inicia más cerca de la menopausia.
Conclusiones:
- La terapia hormonal menopáusica (HT) puede ser una opción de tratamiento valiosa para los molestos síntomas de la menopausia.
- La selección cuidadosa de pacientes, teniendo en cuenta la edad, el tiempo transcurrido desde la menopausia y los factores de riesgo cardiovascular, es crucial.
- Las estrategias de HT personalizadas, incluida la formulación y la ruta, son esenciales para optimizar los beneficios y minimizar los riesgos en mujeres con consideraciones cardiovasculares.
Palabras clave:
Enfermedades cardiovascularesEnfermedad arterial coronariaTerapia de reemplazo hormonalHiperlipidemiashipertensiónla menopausiaTromboembolismo venosoMás Videos Relacionados
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