Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Oral Hypoglycemic Agents: Sulfonylureas01:17

Oral Hypoglycemic Agents: Sulfonylureas

269
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
269
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

214
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
214
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

528
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
528
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

354
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
354
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

203
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
203
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

787
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
787

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Substituent-Dependent Structural Trends in Thermal Condensation of Silanetriols and Disiloxanetetraols.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Dual Modality and Site-differentiated Sentinel Node Mapping in Vulvar Cancer.

Anticancer research·2026
Same author

A General Strategy for the Synthesis of Jerangolids Enabled by π-allyl Stille Coupling.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Flash Communication: (Ph<sub>3</sub>P)<sub>2</sub>N<sub>2</sub>Aza-Wittig Reagent for Metal Carbonyls.

Organometallics·2026
Same author

Pentasilacyclopentadienide: A Hückel aromatic species at the border of resonance and equilibrium.

Science (New York, N.Y.)·2026
Same author

A Crystalline In(II) Hydride.

Journal of the American Chemical Society·2026

Video Experimental Relacionado

Updated: Aug 10, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.7K

Silapiramidanos estables

Taiki Imagawa1,2, Luisa Giarrana1, Diego M Andrada1

  • 1Krupp-Chair for General and Inorganic Chemistry, Saarland University, 66123 Saarbrücken, Germany.

Journal of the American Chemical Society
|February 14, 2023
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores sintetizaron una nueva molécula de silapiramidano utilizando precursores de ciclobutadieno y sileno. Este compuesto de silicio único exhibe una señal de RMN blindada y forma complejos de hierro interesantes y derivados de espirobis (siloles) fluorescentes.

Más Videos Relacionados

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.0K
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

7.0K

Videos de Experimentos Relacionados

Last Updated: Aug 10, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.7K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.0K
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

7.0K

Área de la Ciencia:

  • Química del silicio orgánico
  • Química sintética inorgánica
  • Ciencias de los materiales

Sus antecedentes:

  • Los ciclobutadienos son sistemas cíclicos tensados con una reactividad única.
  • Los sililenos son análogos de silicio de los carbenos, conocidos por su alta reactividad.
  • Las estructuras piramidal son raras en la química del silicio, lo que plantea desafíos sintéticos.

Objetivo del estudio:

  • Para sintetizar y caracterizar una nueva estructura de silapiramidano.
  • Explorar la reactividad del silapiramidano con los carbonilos metálicos y el ciclobutadieno.
  • Investigar las propiedades electrónicas del silapiramidano, incluida su firma de RMN.

Principales métodos:

  • Reacción del tetrakis ((trimetilsililo) ciclobutadieno con un sileno soportado por amidinato.
  • Aislamiento y caracterización de un intermediario de ciclobuteno con un enlace SiC exocíclico.
  • Análisis espectroscópico (29Si NMR) del silapiramidano y sus derivados.

Principales resultados:

  • Síntesis exitosa del elusivo silapiramidano a través de una secuencia de adición-reducción.
  • Observación de una resonancia NMR de 29Si altamente blindada a -448,3 ppm para el ápice de silicio.
  • Formación de un complejo silapiramidano-hierro tras el tratamiento con Fe2(CO)9.
  • La reacción con el ciclobutadieno produce un espirobis (silole) fluorescente.

Conclusiones:

  • El estudio presenta una vía sintética viable para los silapiramidanos.
  • El entorno electrónico único del ápice del átomo de silicio es confirmado por la espectroscopia de RMN.
  • El silapiramidano demuestra una reactividad versátil, permitiendo la formación de complejos organometálicos y nuevos compuestos heterocíclicos.