Video Experimental Relacionado
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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
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El merbecovirus del pangolín se reduce a lo básico
1Department of Infectious Disease, King's College London, London, UK.
Cell
|February 21, 2023
Resumen
El tráfico de mamíferos vivos plantea un riesgo de virus zoonóticos. Un nuevo estudio encontró un coronavirus relacionado con el MERS en pangolines traficados, que exhiben una amplia adaptabilidad de mamíferos y un nuevo sitio de escisión de furin.
Área de la Ciencia:
- Virología
- Enfermedades zoonóticas
- Comercio de especies silvestres
Sus antecedentes:
- El tráfico de mamíferos vivos es una vía importante para la aparición de virus zoonóticos.
- Los pangolines, los mamíferos más traficados a nivel mundial, se han relacionado previamente con los coronavirus relacionados con el SARS-CoV-2.
Objetivo del estudio:
- Investigar la presencia y las características de los coronavirus en los pangolines traficados.
- Para evaluar el potencial zoonótico de los coronavirus identificados.
Principales métodos:
- Análisis filogenético del material genético viral.
- Análisis in silico de las estructuras y funciones de las proteínas virales.
Principales resultados:
- Identificación de un coronavirus relacionado con el MERS en pangolines traficados.
- El coronavirus identificado demuestra un amplio tropismo en varias especies de mamíferos.
- Se detectó un sitio de escisión de furin recién adquirido en la proteína Spike del coronavirus relacionado con MERS.
Conclusiones:
- Los pangolines traficados albergan coronavirus relacionados con el MERS con un potencial zoonótico significativo.
- La presencia de un sitio de escisión de furin sugiere una mayor capacidad de entrada y transmisión viral.
- Este hallazgo subraya la necesidad urgente de mejorar la vigilancia y la regulación del comercio de especies silvestres para mitigar los riesgos de pandemia.
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