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Autoimmune Disorders01:29

Autoimmune Disorders

572
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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What is the Immune System?01:38

What is the Immune System?

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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Video Experimental Relacionado

Updated: Aug 6, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Autoinmunidad al yo modificado

Laura Santambrogio1,2,3

  • 1Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.

Science (New York, N.Y.)
|March 17, 2023
PubMed
Resumen
Este resumen es generado por máquina.

Las modificaciones de las proteínas pueden llevar al sistema inmunológico a atacar las propias proteínas del cuerpo. Este desglose de la auto-tolerancia es un factor clave en las enfermedades autoinmunes.

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Área de la Ciencia:

  • Inmunología
  • La bioquímica
  • Biología molecular

Sus antecedentes:

  • El sistema inmunológico normalmente distingue entre antígenos propios y no propios.
  • El deterioro de la auto tolerancia está implicado en la patogénesis de las enfermedades autoinmunes.
  • Las modificaciones postraslacionales de proteínas (PTM) alteran la estructura y la función de las proteínas.

Objetivo del estudio:

  • Investigar cómo las modificaciones postraslacionales de proteínas afectan la tolerancia inmune.
  • Comprender los mecanismos por los cuales los PTM pueden romper la auto-tolerancia.

Principales métodos:

  • Análisis de las autoproteínas modificadas.
  • Ensayos inmunológicos para evaluar las respuestas de las células T y B.
  • Espectrometría de masas para identificar y caracterizar las PTM.

Principales resultados:

  • Se encontró que las modificaciones post-traduccionales de proteínas específicas generan neoantígenos.
  • Estos neoantígenos pueden provocar respuestas autoinmunes.
  • El estudio identificó los PTM clave que alteran la tolerancia inmune.

Conclusiones:

  • Las modificaciones postraslacionales de las proteínas representan un mecanismo significativo para romper la autotolerancia.
  • La orientación de los PTM puede ofrecer nuevas estrategias terapéuticas para las enfermedades autoinmunes.