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El tálamo impulsa los comienzos vocales en la canción de cortejo del pinzón cebra
Felix W Moll1,2,3, Devorah Kranz1,2, Ariadna Corredera Asensio1,2
1NYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA.
Nature
|March 23, 2023
Resumen
El tálamo motor dirige las secuencias vocales mediante la activación específica
Área de la Ciencia:
- La neurociencia
- Biología del comportamiento
- Neurociencia auditiva
Sus antecedentes:
- Las entradas de largo alcance influyen críticamente en la ejecución de la acción en los circuitos corticales motores.
- Las proyecciones tálamicas dan forma a la actividad premotora y pueden seleccionar acciones estereotipadas para comportamientos complejos.
Objetivo del estudio:
- Investigar los mecanismos de interacción entre el tálamo y la corteza motora en la ejecución de movimientos secuenciales.
- Determinar el papel de las entradas del tálamo en la progresión de la secuencia vocal.
Principales métodos:
- Imágenes de dos fotones in vivo de los axones tálamicos en el núcleo de la canción de los pinzones cebra.
- Perturbación en línea de la función tálamic durante el canto.
- Estimulación del tálamo para identificar y caracterizar las neuronas talamorreceptoras en CVH.
Principales resultados:
- El impulso tálamico involucra a una subpoblación específica (~ 15%) de neuronas premotoras de CVH.
- Estas neuronas talamorreceptoras están activas antes del inicio de la sílaba.
- La función tálamic perturbadora trunca las canciones en los límites de la sílaba.
Conclusiones:
- La entrada talámica es crítica para la progresión entre los elementos motores vocales (sílabas).
- El tálamo puede iniciar componentes de la canción dirigiéndose a "células iniciales" específicas dentro de HVC.
- El tálamo motor actúa como director de la dinámica cortical en comportamientos secuenciales.
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