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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Bases de la especificidad H2AK119 de la deubiquitinasa represiva de Polycomb

Weiran Ge1,2, Cong Yu1,2, Jingjing Li1,2

  • 1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Nature
|March 29, 2023
PubMed
Resumen

El complejo de deubiquitinasa represiva Polycomb (PR-DUB) se dirige con precisión a H2AK119ub1 en los nucleosomas. Las ideas estructurales revelan cómo la unión de ASXL1 y BAP1 al ADN y las histonas asegura este mecanismo específico de regulación génica.

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