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La retroalimentación cortico-cortical involucra a las dendritas activas en la corteza visual
Mehmet Fişek1, Dustin Herrmann2, Alexander Egea-Weiss2
1Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. fisekm@gmail.com.
Nature
|May 3, 2023
Resumen
La retroalimentación neocortical de las áreas visuales superiores a la corteza visual primaria está organizada espacialmente. Esta retroalimentación facilita la percepción cuando se compensa espacialmente, integrándose de manera no lineal en las dendritas.
Área de la Ciencia:
- La neurociencia
- Investigación de la corteza visual
- Circuitos corticales
Sus antecedentes:
- El procesamiento sensorial se basa en las vías de alimentación y retroalimentación en la neocórtex.
- La retroalimentación proporciona información contextual, ayudando a la percepción, pero sus mecanismos son poco conocidos.
Objetivo del estudio:
- Investigar el circuito y los mecanismos celulares de la influencia de retroalimentación desde el área visual lateromedial (LM) hasta la corteza visual primaria (V1).
- Comprender cómo la retroalimentación organizada espacialmente contribuye a la percepción visual.
Principales métodos:
- Mapa de conectividad óptica de largo alcance en ratones.
- Imágenes de calcio de dos fotones en las neuronas piramidal V1.
- La optogenética de dos fotones para activar las neuronas LM.
Principales resultados:
- La retroalimentación de LM a V1 está organizada espacialmente: supresora cuando está alineada, facilitando cuando está desplazada en el espacio visual.
- La retroalimentación facilitadora está integrada de manera no lineal en las dendritas del tufo apical de las neuronas piramidal V1.
- La estimulación de las neuronas LM que se proyectan a V1 impulsa señales de calcio dendríticas específicas de la rama.
Conclusiones:
- La conectividad de retroalimentación neocortical está organizada espacialmente y juega un papel en las interacciones contextuales.
- La integración dendrítica no lineal de retroalimentación apoya las funciones perceptivas predictivas y cooperativas.
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