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Updated: Jul 29, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

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Conocimientos estructurales y funcionales sobre el transporte mediado por Spns2 de esfingosina-1-fosfato

Hongwen Chen1, Shahbaz Ahmed2, Hongtu Zhao2

  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|May 24, 2023
PubMed
Resumen

El homólogo de Spinster 2 (Spns2) transporta el esfingosina-1-fosfato (S1P) mediante difusión facilitada. Las ideas estructurales revelan su ciclo de transporte y cómo los inhibidores como 16d bloquean la exportación de S1P, ayudando al desarrollo de fármacos.

Palabras clave:
S1P (en inglés)Spns2 (en inglés)Crio-EMSuperfamilia de los principales facilitadoresEsfingolipídicouniportero

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