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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
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CD19: Células CAR T dirigidas para la miositis y la enfermedad pulmonar intersticial asociada con el síndrome de la
Ann-Christin Pecher1, Luca Hensen1, Reinhild Klein1
1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany.
JAMA
|June 27, 2023
Resumen
La terapia con células T CAR dirigidas a CD19 es prometedora para el síndrome de la antisintetasa refractaria. Este tratamiento condujo a una mejora clínica significativa y a la normalización de los biomarcadores clave en un caso grave.
Área de la Ciencia:
- Inmunología
- Terapia con células
- Reumatología
Sus antecedentes:
- El síndrome de la antisintetasa es un trastorno autoinmune grave caracterizado por miositis y enfermedad pulmonar intersticial.
- Los casos refractarios plantean desafíos significativos, lo que requiere nuevas estrategias terapéuticas.
- Las células T del receptor del antígeno quimérico (CAR) dirigidas a CD19 han surgido como un agente inmunosupresor potencial.
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