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Integración autónoma en las comunidades de protocélulas anidadas
Zhuping Yin1, Ning Gao1,2, Can Xu1
1Centre for Protolife Research, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
Journal of the American Chemical Society
|June 27, 2023
Resumen
Los investigadores crearon comunidades de protocélulas auto-organizadas y anidadas que imitan los sistemas multicelulares. Estas comunidades celulares artificiales exhiben funciones coordinadas y pueden estabilizarse o desintegrarse a pedido.
Área de la Ciencia:
- Ciencias de los materiales biomiméticos
- Biología sintética
- Física de la materia blanda
Sus antecedentes:
- Las protocélulas modelo ofrecen una plataforma para comprender los orígenes de la vida y construir sistemas celulares artificiales.
- Lograr un comportamiento coordinado y una organización de orden superior en células sintéticas sigue siendo un desafío significativo.
Objetivo del estudio:
- Desarrollar un mecanismo semiautónomo para crear comunidades de protocélulas anidadas y simbióticas.
- Para explorar la auto-organización y la integración funcional de los sistemas celulares artificiales.
- Diseñar materiales citomiméticos reconfigurables con propiedades estructurales y funcionales complejas.
Principales métodos:
- Utilizó una vía similar a la endosimbiótica para capturar proteinosomas dentro de las vesículas coacervadas de alginato/fibroína de seda.
- Cambios morfológicos demostrados en las vesículas coacervas mediados por la actividad enzimática (ureasa/glucosa oxidasa).
- Procesos impulsados por combustible para la capacidad de conducción autónoma y el refuerzo de la matriz mediado por enzimas para la estabilización estructural.
Principales resultados:
- Se han formado con éxito comunidades anidadas discretas de protocélulas con actividad catalítica integrada.
- Mostró la desintegración selectiva de estas comunidades.
- Se logra la estabilización estructural a través del ensamblaje supramolecular de dipeptidos y el enlace cruzado tiramina-alginato.
- Modulación demostrada de la capacidad de conducción automática a través de hidrolasas de almidón internalizadas.
Conclusiones:
- El estudio presenta un nuevo mecanismo semiautónomo para construir comunidades anidadas simbióticas similares a las células.
- Este trabajo avanza en el desarrollo de la multicelularidad artificial y los materiales citomiméticos reconfigurables.
- Los hallazgos abren vías para la creación de materiales con complejidad estructural, funcional y organizativa emergente.
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