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Introducción de pares de Lewis frustrados en el marco metal-orgánico para la hidrogenación selectiva de

Ze-Ming Xu¹, Zhuoyi Hu¹, Yali Huang¹

¹College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China.

Journal of the American Chemical Society

|June 29, 2023

Resumen

Un nuevo marco metal-orgánico (MOF) de tipo P/B frustrado por el catalizador de par de Lewis (FLP) hidrogena eficientemente los heterociclos N. Este catalizador heterogéneo ofrece altos rendimientos y reciclabilidad para la síntesis de compuestos farmacéuticos.

Área de la Ciencia:

Catálisis
Ciencias de los materiales
Química orgánica

Sus antecedentes:

Los heterociclos de nitrógeno hidrogenado son vitales en productos farmacéuticos, polímeros y productos agroquímicos.
Los catalizadores de metales preciosos para la hidrogenación son a menudo costosos y tóxicos.
Los pares de Lewis frustrados (FLP) son catalizadores efectivos del grupo principal, pero los MOF-FLP mostraron previamente una baja reactividad para los heterociclos N.

Objetivo del estudio:

Desarrollar un catalizador heterogéneo altamente eficiente y reciclable para la hidrogenación de N-heterociclos.
Para superar las limitaciones de baja reactividad de los MOF-FLP anteriores.
Para sintetizar nuevos catalizadores MOF-FLP de tipo P/B para la hidrogenación selectiva.

Principales métodos:

Se utilizó un enfoque de incorporación de enlaces asistido por solvente para sintetizar el MOF-FLP de tipo P/B.
El catalizador se probó para la hidrogenación selectiva de la quinolina y el indole utilizando gas hidrógeno.
Las condiciones de reacción implicaron una presión de hidrógeno moderada.

Principales resultados:

El nuevo MOF-FLP de tipo P/B demostró una alta eficiencia catalítica para la hidrogenación.
La hidrogenación selectiva de la quinolina a la tetrahidroquinolina y el indol a la indolina se logró en rendimientos altos.
El catalizador heterogéneo mostró una excelente reciclabilidad, lo que indica su utilidad práctica.

Conclusiones:

El MOF-FLP de tipo P/B desarrollado es un catalizador heterogéneo altamente eficiente para la hidrogenación selectiva de N-heterociclos.
Este enfoque ofrece una alternativa prometedora a los catalizadores de metales preciosos en la síntesis farmacéutica.
El sistema MOF-FLP mejora el rendimiento del catalizador y la reciclabilidad.

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