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Videos de Conceptos Relacionados

Tissues01:18

Tissues

Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
Tissue Membranes01:27

Tissue Membranes

A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Video Experimental Relacionado

Updated: May 13, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
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El transcriptoma espacial de una sola célula revela la organización del tipo celular en la corteza del macaco

Ao Chen1, Yidi Sun2, Ying Lei3

  • 1BGI-Shenzhen, Shenzhen 518103, China; Department of Biology, University of Copenhagen, Copenhagen 2200, Denmark; BGI Research-Southwest, BGI, Chongqing 401329, China; JFL-BGI STOmics Center, Jinfeng Laboratory, Chongqing 401329, China.

Cell
|July 13, 2023
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores mapearon 264 tipos de células en la corteza cerebral del macaco utilizando una secuenciación avanzada. Este atlas cerebral revela la distribución celular vinculada a la jerarquía cerebral e identifica los tipos de células específicas de los primates, lo que ayuda a la investigación futura en neurociencia.

Palabras clave:
Organización por tipo de célulala jerarquíaCorteza del macacode una sola celdatranscriptoma espacial

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Área de la Ciencia:

  • La neurociencia
  • La genómica
  • Biología celular

Sus antecedentes:

  • Comprender la organización celular de la corteza cerebral es clave para el funcionamiento del cerebro.
  • Los estudios anteriores carecían de un mapa completo de los tipos de células y su distribución espacial.

Objetivo del estudio:

  • Para crear un atlas detallado de los tipos de células corticales del macaco y su organización espacial.
  • Investigar la relación entre la distribución celular, la jerarquía cortical y los tipos celulares específicos de los primates.

Principales métodos:

  • Secuenciación de ARN de un solo núcleo a gran escala.
  • Análisis transcriptómico espacial en 143 regiones corticales de macaco.
  • Comparación transcriptómica entre especies (humano, macaco y ratón).

Principales resultados:

  • Atlas completo de 264 tipos de células corticales definidas por el transcriptoma.
  • Distribución espacial de los tipos de células a través de la corteza del macaco.
  • Descubrió vínculos entre la distribución celular, la jerarquía regional y los tipos celulares específicos de los primates enriquecidos en la capa 4.

Conclusiones:

  • Proporciona una base celular y molecular para la evolución, el desarrollo y la enfermedad del cerebro de los primates.
  • Destaca la importancia de la organización espacial en la función cortical.
  • Identifica nuevos tipos celulares específicos de primates con expresión génica dependiente de la región.