Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

215
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
215
Seizures: Classification01:13

Seizures: Classification

426
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
426
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

427
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
427
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

349
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
349
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

467
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
467
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

215
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
215

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Novel epilepsy treatments in clinical development.

Epilepsy & behavior : E&B·2026
Same author

Timing for Starting Antiseizure Medication Withdrawal After Epilepsy Surgery in Adults.

Neurology·2026
Same author

Attitude of people with epilepsy in Serbia toward surgical treatment of epilepsy.

Epilepsia open·2025
Same author

Altered along-the-perivascular space index in functional (psychogenic non-epileptic) seizures: A diffusion tensor imaging study of glymphatic system function.

Epilepsia open·2025
Same author

Substance use, depression, and anxiety: A cross-sectional study comparing adolescents with epilepsy and diabetes.

Epilepsy & behavior : E&B·2025
Same author

Continuing medical education in epileptology: The Level 1-2-3 experience of the ILAE academy.

Epileptic disorders : international epilepsy journal with videotape·2025

Video Experimental Relacionado

Updated: Jul 23, 2025

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

9.6K

Epilepsia en adultos

Ali A Asadi-Pooya1, Francesco Brigo2, Simona Lattanzi3

  • 1Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.

Lancet (London, England)
|July 17, 2023
PubMed
Resumen
Este resumen es generado por máquina.

El diagnóstico de la epilepsia es clínico, ayudado por investigaciones. Mientras que los medicamentos anticonvulsivos ayudan a dos tercios de los pacientes, la cirugía y otras terapias ofrecen opciones para la epilepsia resistente a los medicamentos.

Más Videos Relacionados

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.1K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.7K

Videos de Experimentos Relacionados

Last Updated: Jul 23, 2025

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

9.6K
Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.1K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.7K

Área de la Ciencia:

  • Neurología
  • Medicina Clínica

Sus antecedentes:

  • La epilepsia es un trastorno neurológico generalizado que afecta a diversas poblaciones en todo el mundo.
  • El diagnóstico se basa en la evaluación clínica, apoyada por electroencefalografía e imágenes para el tipo, la causa y el pronóstico.
  • Los medicamentos anticonvulsivos actuales son efectivos para aproximadamente dos tercios de las personas.

Objetivo del estudio:

  • Describir las estrategias actuales de diagnóstico y tratamiento de la epilepsia.
  • Para resaltar el papel de los medicamentos, la cirugía y las intervenciones no farmacológicas.

Principales métodos:

  • El diagnóstico clínico y las investigaciones auxiliares (EEG, imágenes).
  • Tratamientos farmacológicos (medicamentos anticonvulsivos)
  • Las intervenciones quirúrgicas (resección, cirugía paliativa) y las opciones no farmacológicas (neuromodulación, intervenciones dietéticas).

Principales resultados:

  • Los medicamentos anticonvulsivos controlan eficazmente las convulsiones en aproximadamente el 67% de los pacientes.
  • La resección neuroquirúrgica es efectiva para casos seleccionados de epilepsia focal resistente a los medicamentos.
  • La cirugía paliativa, la neuromodulación y las terapias dietéticas son opciones para la epilepsia resistente a los medicamentos cuando la resección no es factible.

Conclusiones:

  • El tratamiento de la epilepsia implica un enfoque multifacético.
  • Los medicamentos son el tratamiento principal, pero las opciones quirúrgicas y no farmacológicas son cruciales para los casos refractarios.