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Una fuente de energía iónica suave a microescala modula la actividad de la red neuronal

Yujia Zhang1, Jorin Riexinger2, Xingyun Yang2

  • 1Department of Chemistry, University of Oxford, Oxford, UK. yujia.zhang@chem.ox.ac.uk.

Nature
|August 30, 2023
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores desarrollaron una fuente de energía suave miniaturizada utilizando gotas de hidrogel para dispositivos biointegrados. Este nuevo generador de corriente iónica ofrece energía bajo demanda para la estimulación biológica a microescala.

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Área de la Ciencia:

  • Biotecnología
  • Ciencias de los materiales
  • La neurociencia

Sus antecedentes:

  • Los dispositivos biointegrados requieren fuentes de energía eficientes a microescala.
  • Las soluciones de energía existentes a menudo no son biocompatibles, flexibles o accionadas iónicamente.
  • Las fuentes de energía miniaturizadas que almacenan y liberan energía bajo demanda son difíciles de crear.

Objetivo del estudio:

  • Desarrollar una fuente de energía miniaturizada, suave y biocompatible para la estimulación biológica a microescala.
  • Crear una fuente de energía que genere corriente iónica, inspirada en sistemas biológicos.
  • Permitir el funcionamiento bajo demanda para modular la actividad celular y tisular.

Principales métodos:

  • Fabricación de redes soportadas por lípidos de gotas de hidrogel de nanolitros.
  • Utilizando gradientes de iones internos dentro de las gotas de hidrogel para generar energía.
  • Caracterización de la densidad de potencia, el almacenamiento de energía y la biocompatibilidad.

Principales resultados:

  • Desarrolló una fuente de energía suave miniaturizada con una reducción de volumen de más de 10^5 veces en comparación con los diseños anteriores.
  • Se logró el almacenamiento de energía durante más de 24 horas, lo que permite el funcionamiento bajo demanda.
  • Se ha demostrado un aumento de 680 veces en la densidad de potencia (aprox. En el caso de los vehículos eléctricos, el

Conclusiones:

  • El nuevo dispositivo de gotas de hidrogel funciona como una fuente de corriente iónica biocompatible.
  • Se ha modulado con éxito la actividad de la red neuronal en micro tejidos neurales 3D y en cortes cerebrales de ratón ex vivo.
  • Este dispositivo ionotrónico de microescala suave tiene potencial para la integración en organismos vivos.