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Updated: Aug 14, 2026
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Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Resumen
El abuso de pentazocina y tripelennamina, conocido como "T's and blues", continúa con una nueva formulación. La adición de clorhidrato de naloxona a la pentazocina no impidió el abuso con tripelenamina.
Área de la Ciencia:
- Farmacología Farmacología.
- Toxicología Toxicología.
- Medicina de la adicción Medicina de la adicción
Sus antecedentes:
- La combinación de pentazocina y clorhidrato de tripelenamina fue un sustituto común de la heroína.
- Una nueva formulación, Talwin Nx, incluye clorhidrato de naloxona para disuadir el abuso.
- La naloxona es un antagonista narcótico de acción corta.
Objetivo del estudio:
- Informar de dos casos de abuso relacionados con la nueva formulación de pentazocina y naloxona combinada con tripelenamina.
- Explorar las posibles razones por las cuales la naloxona no pudo antagonizar los efectos de la pentazocina en estos casos.
Principales métodos:
- Análisis del informe de caso. análisis del informe de caso.
- Revisión de la literatura sobre el abuso de drogas y la farmacodinámica.
Principales resultados:
- Se documentaron dos casos de abuso de Talwin Nx y tripelennamine.
- La naloxona en Talwin Nx no impidió los efectos eufóricos o deseados cuando se abusó con tripelennamine.
Conclusiones:
- El abuso de pentazocina y tripelenamina continúa a pesar de la inclusión de naloxona en las formulaciones más nuevas.
- Se necesitan más investigaciones para comprender los mecanismos por los cuales los efectos antagonistas de la naloxona pueden eludirse en este escenario de abuso de la combinación.
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