Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Preclinical Development: Overview01:28

Preclinical Development: Overview

4.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.5K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
Pharmacovigilance01:19

Pharmacovigilance

876
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
876
Drug Elimination: The Concept of Clearance01:06

Drug Elimination: The Concept of Clearance

2.7K
Drug elimination refers to removing drugs from the body, either through urine by the kidneys or through bile by the liver. Drug clearance is a pharmacokinetic parameter that measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the plasma concentration of the drug.
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination,...
2.7K
Drug Regulation01:25

Drug Regulation

1.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.4K
Ethical Standards I01:25

Ethical Standards I

837
The American Nurses Association (ANA) created and implemented the first nationally accepted Code of Ethics for Nurses with Interpretive Statements. The Code of Ethics is a living document regularly updated by the ANA and establishes an ethical standard that is non-negotiable for nurses in all roles and settings.
The Code of Ethics provisions outline the nurse's duty to the patient, the healthcare team, the profession, and society. The Code's fundamental principles include advocacy,...
837

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Elective genomic sequencing for adults in research, clinical and commercial contexts.

BMC medical genomics·2026
Same author

Toward a nuanced framework for the Medical development of ibogaine and its analogues and derivatives: implications for psychopharmacology.

Expert opinion on drug discovery·2026
Same author

The Psychedelic Therapies Executive Order: On Approval and Clinical Readiness.

JAMA·2026
Same author

Elective genomic sequencing for adults in research, clinical and commercial contexts.

medRxiv : the preprint server for health sciences·2026
Same author

Public attitudes toward cascade genetic screening in the United States.

Health affairs scholar·2026
Same author

Multi-Omics Characterization of Human Molecular Responses to Spaceflight Across Two Independent Missions.

bioRxiv : the preprint server for biology·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jul 15, 2025

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator
07:06

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator

Published on: May 14, 2020

5.1K

¿Está autorizado éticamente para el lanzamiento?

Vasiliki Rahimzadeh1, Jennifer Fogarty2, Timothy Caulfield3

  • 1Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA.

Science (New York, N.Y.)
|September 28, 2023
PubMed
Resumen
Este resumen es generado por máquina.

La investigación humana en vuelos espaciales comerciales requiere directrices claras. El establecimiento de estas normas es esencial para la seguridad y la conducta ética en este campo emergente.

Más Videos Relacionados

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System
04:55

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System

Published on: November 22, 2016

6.8K
Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

3.4K

Videos de Experimentos Relacionados

Last Updated: Jul 15, 2025

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator
07:06

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator

Published on: May 14, 2020

5.1K
Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System
04:55

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System

Published on: November 22, 2016

6.8K
Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

3.4K

Área de la Ciencia:

  • Investigación de vuelos espaciales
  • Fisiología humana en el espacio
  • Exploración comercial del espacio

Sus antecedentes:

  • Aumento de la participación del sector privado en las misiones espaciales.
  • Los desafíos únicos de llevar a cabo investigaciones sobre sujetos humanos fuera de la atmósfera de la Tierra.
  • La actual falta de marcos normativos específicos para la investigación espacial humana comercial.

Objetivo del estudio:

  • Resaltar la necesidad de establecer marcos regulatorios para la investigación humana en vuelos espaciales comerciales.
  • Identificar las áreas clave que requieren normas y directrices específicas.
  • Abogar por el desarrollo de normas éticas y de seguridad.

Principales métodos:

  • Revisión de las normas vigentes en materia de investigación espacial.
  • Análisis de riesgos potenciales y consideraciones éticas para sujetos humanos en vuelos espaciales comerciales.
  • Estudio comparativo de los enfoques regulatorios en otros entornos de investigación de alto riesgo.

Principales resultados:

  • Las regulaciones actuales son insuficientes para el contexto único de los vuelos espaciales comerciales.
  • Se necesitan directrices específicas para la selección de participantes, el consentimiento informado, la privacidad de los datos y los protocolos de emergencia.
  • Un enfoque proactivo de la regulación es crucial antes de que comience la investigación comercial en humanos.

Conclusiones:

  • Las normas formalizadas son imprescindibles para el avance responsable de la investigación humana en el vuelo espacial comercial.
  • El desarrollo de estas regulaciones garantizará la seguridad de los participantes, la integridad de los datos y las prácticas éticas de investigación.
  • La colaboración internacional puede ser beneficiosa para la creación de directrices exhaustivas.