Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

13.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.6K
Cell Diversity01:13

Cell Diversity

3.2K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
3.2K
Cellular Differentiation00:57

Cellular Differentiation

2.7K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
2.7K
Determination01:51

Determination

18.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.5K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Multimodal characterization of variation in neuronal types in the mouse basal ganglia.

bioRxiv : the preprint server for biology·2026
Same author

Connecting single-cell transcriptomes to projectomes in the mouse visual cortex.

Nature·2026
Same author

Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.

Research square·2026
Same author

Conserved Cell Type Signatures Across the Brainstem and Spinal Cord in the Mouse Central Nervous System.

bioRxiv : the preprint server for biology·2026
Same author

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms.

Nature methods·2026
Same author

A layered standards framework for integrating single-cell and spatial omics data into brain cell atlases.

bioRxiv : the preprint server for biology·2026

Video Experimental Relacionado

Updated: Jul 13, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K

Variación interindividual en la abundancia y expresión del tipo de células corticales humanas

Nelson Johansen1, Saroja Somasundaram1, Kyle J Travaglini1

  • 1Allen Institute for Brain Science, Seattle, WA 98109, USA.

Science (New York, N.Y.)
|October 12, 2023
PubMed
Resumen

Este estudio mapea los tipos de células neocorticales en 75 individuos, revelando una variación interindividual significativa en la abundancia celular y la expresión génica, especialmente en poblaciones específicas de neuronas y microglías. Esto proporciona una línea de base para comprender la variación celular en la salud y la enfermedad.

Más Videos Relacionados

Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.2K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.1K

Videos de Experimentos Relacionados

Last Updated: Jul 13, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K
Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.2K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.1K

Área de la Ciencia:

  • La neurociencia
  • La genómica
  • Biología celular

Sus antecedentes:

  • La transcriptómica unicelular ha identificado tipos de células neocorticales conservadas.
  • Los estudios anteriores se vieron limitados por el pequeño tamaño de las muestras post mortem.

Objetivo del estudio:

  • Caracterizar la variación del tipo celular en una gran cohorte de individuos adultos.
  • Para establecer una línea de base para la variación celular en el neocórtex humano.

Principales métodos:

  • Secuenciación de ARN de un solo núcleo de tejido neocortical de 75 pacientes quirúrgicos adultos.
  • Análisis de la abundancia del tipo celular y las firmas de expresión génica.
  • Correlación de la variación genómica con la expresión génica.

Principales resultados:

  • Identificación de 125 tipos de células neocorticales robustas en el giro temporal medio.
  • Significativa variación interindividual en las abundancias celulares y la expresión génica, particularmente en las neuronas glutamatérgicas de capa profunda y la microglía.
  • La variación genómica asociada con la expresión de 150-250 genes en la mayoría de los tipos de células.

Conclusiones:

  • Los tipos de células neocorticales humanas exhiben una variación interindividual sustancial.
  • La edad, el sexo, la ascendencia, la enfermedad y el estado celular explican una minoría de esta variación.
  • Esta caracterización integral sirve como una línea de base crucial para futuros estudios en salud y enfermedad neurológicas.