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Elucidación de los determinantes celulares de la degradación de las proteínas de la membrana dirigida por quimeras

Green Ahn1,2, Nicholas M Riley1,2, Roarke A Kamber3

  • 1Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|October 19, 2023
PubMed
Resumen

La alteración de los genes de los retrómeros mejora la degradación de las proteínas de la membrana por la quimera dirigida a los lisosomas (LYTAC) al limitar el reciclaje de LYTAC. La inhibición de la biosíntesis de cullina-3 y M6P nedilada optimiza aún más la eficacia de LYTAC para el desarrollo terapéutico.

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