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Mortalidad en ensayos controlados aleatorios con dispositivos recubiertos de paclitaxel para procedimientos de

Sahil A Parikh¹, Peter A Schneider², Christopher M Mullin³

¹Columbia University Irving Medical Center, New York, NY, USA.

Lancet (London, England)

|October 27, 2023

Resumen

El análisis actualizado de los dispositivos recubiertos de paclitaxel no muestra un aumento del riesgo de mortalidad. Este análisis agrupado a nivel de paciente proporciona garantías sobre la seguridad de estos dispositivos para el tratamiento de la enfermedad femoropolítica oclusiva.

Área de la Ciencia:

Medicina vascular
Cardiología intervencionista
Ciencia de los biomateriales

Sus antecedentes:

Los dispositivos recubiertos de paclitaxel se utilizan para la enfermedad de oclusión femoropólita.
Un metanálisis previo sugirió un mayor riesgo de mortalidad con los dispositivos recubiertos de paclitaxel.
Este estudio proporciona un análisis actualizado de la seguridad utilizando datos completos de ensayos.

Conclusiones:

Este metanálisis no encontró ninguna asociación entre la exposición al dispositivo recubierto con paclitaxel y el riesgo de mortalidad.
Los resultados ofrecen tranquilidad con respecto a la seguridad de los dispositivos recubiertos de paclitaxel para la enfermedad femoroplítea.
Los hallazgos apoyan el uso clínico actual y la aceptación reglamentaria.

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