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Una fuerte biointerfaz de liberación rápida en mejillones mediada por la adhesión basada en cilios serotoninérgicos
Jenaes Sivasundarampillai1, Lucia Youssef1, Tobias Priemel1
1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
Science (New York, N.Y.)
|November 16, 2023
Resumen
Los mejillones se desprenden de sus fuertes anclas de byssus utilizando cilios móviles en la biointerfaz. Este proceso regulado neuroquímicamente les permite liberar y reubicarse cuando se enfrentan al estrés ambiental.
Área de la Ciencia:
- Ciencia de los biomateriales
- Biología marina
- Ingeniería de tejidos
Sus antecedentes:
- Los anclajes de bisus de mejillón proporcionan una biointerfaz robusta entre los tejidos biológicos y los materiales no biológicos.
- El mecanismo por el cual los mejillones se desprenden y regeneran sus anclas de bisso sigue siendo poco conocido.
Objetivo del estudio:
- Investigar la estructura y la composición de la biointerfaz de bisus de mejillón.
- Aclarar el mecanismo de liberación y regeneración del tallo de bisso.
Principales métodos:
- Histología
- Mapeo Raman confocal
- Tomografía microcomputada mejorada por contraste de fase
- Microscopía electrónica avanzada
Principales resultados:
- La biointerfaz de byssus presenta hojas de biopolímero abiótico interdigitadas con la matriz extracelular viva.
- Los cilios epiteliales móviles en las superficies de la lámina median la fuerza de la biointerfaz y la liberación del tallo.
- El movimiento colectivo impulsado por los cilios, regulado neuroquímicamente, controla el desprendimiento de byssus.
Conclusiones:
- Los mejillones poseen un sofisticado mecanismo de biointerfaz para el desprendimiento del anclaje y la regeneración.
- La regulación neuroquímica de los cilios sugiere una vía sensorial para que los mejillones respondan al estrés ambiental y se reubiquen.
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