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Síndrome de Cushing

Mônica Gadelha1, Federico Gatto2, Luiz Eduardo Wildemberg3

  • 1Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Neuroendocrine Unit, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil; Molecular Genetics Laboratory, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil; Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil.

Lancet (London, England)
|November 20, 2023
PubMed
Resumen
Este resumen es generado por máquina.

El síndrome de Cushing endógeno, causado por el exceso de glucocorticoides, presenta desafíos de diagnóstico y manejo. Esta revisión actualiza aspectos clave del diagnóstico, las complicaciones y el tratamiento para mejorar los resultados de los pacientes.

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Área de la Ciencia:

  • Endocrinología
  • Médico interno
  • Biología molecular

Sus antecedentes:

  • El síndrome de Cushing endógeno (SC) se caracteriza por un exceso de secreción endógena de glucocorticoides.
  • Lleva a diversos problemas clínicos, comorbilidades y una mayor mortalidad, incluso con tratamiento.
  • A pesar de los avances, el diagnóstico y el tratamiento de la esclerosis múltiple siguen siendo complejos.

Objetivo del estudio:

  • Para proporcionar una visión general actualizada del síndrome de Cushing endógeno.
  • Para cubrir aspectos cruciales del diagnóstico, las complicaciones asociadas y las estrategias de tratamiento actuales.
  • Subrayar la importancia de una intervención oportuna para mitigar los problemas de salud a largo plazo.

Principales métodos:

  • Revisión de la literatura reciente sobre los mecanismos moleculares y las alteraciones genéticas en CS.
  • Evaluación de los avances en el diagnóstico por imágenes y las pruebas bioquímicas.
  • Análisis de las opciones de tratamiento quirúrgico y médico actuales.

Principales resultados:

  • Avances significativos en la comprensión de las vías moleculares y los fundamentos genéticos de la CS.
  • Mejora de la precisión del diagnóstico mediante la mejora de las imágenes y los ensayos bioquímicos.
  • Desarrollo de nuevas terapias médicas junto con enfoques quirúrgicos establecidos.

Conclusiones:

  • El diagnóstico preciso y rápido de la esclerosis múltiple endógena es fundamental.
  • La gestión eficaz requiere un enfoque multidisciplinario, que integre la cirugía y las terapias médicas avanzadas.
  • Abordar las comorbilidades persistentes es esencial para mejorar la calidad de vida a largo plazo de los pacientes con esclerosis múltiple.