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Videos de Conceptos Relacionados

Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

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Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Layers of the Epidermis01:21

Layers of the Epidermis

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The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
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Introduction to the Integumentary System01:25

Introduction to the Integumentary System

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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
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Video Experimental Relacionado

Updated: Jul 10, 2025

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing
07:07

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Published on: December 13, 2016

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Propiedades mecánicas de la piel

Samhita P Banavar1, Celeste M Nelson1,2

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.

Science (New York, N.Y.)
|November 23, 2023
PubMed
Resumen
Este resumen es generado por máquina.

Los morfógenos guían el brote de las plumas alterando la mecánica de los tejidos. Este estudio revela cómo estas moléculas de señalización influyen en las propiedades físicas del desarrollo de la piel para iniciar la formación de plumas.

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Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
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Área de la Ciencia:

  • Biología del desarrollo
  • Mecánica de los tejidos
  • Morfogénesis

Sus antecedentes:

  • El brote de plumas es un proceso de desarrollo complejo.
  • El papel de los morfógenos en el inicio de la formación de plumas no se comprende completamente.
  • Se sabe que la mecánica de los tejidos juega un papel en el desarrollo embrionario.

Objetivo del estudio:

  • Para investigar cómo los morfógenos influyen en la mecánica de los tejidos durante el brote de las plumas.
  • Aclarar los mecanismos por los cuales las variaciones en la mecánica de los tejidos promueven la formación de cogollos de plumas.

Principales métodos:

  • Utilizó el modelado computacional para simular gradientes morfógenos.
  • Cambios analizados en la elasticidad y la viscosidad de los tejidos.
  • Observación del desarrollo de las plumas en embriones de pollo.

Principales resultados:

  • Se demostró que las concentraciones específicas de morfógeno inducen cambios localizados en la rigidez de los tejidos.
  • Mostró una correlación entre la mecánica alterada del tejido y el inicio de la formación de placos de plumas.
  • Se han identificado las principales vías de señalización involucradas en la mecanotransducción.

Conclusiones:

  • Las alteraciones inducidas por el morfógeno en la mecánica de los tejidos son cruciales para el brote de las plumas.
  • Este estudio proporciona un vínculo mecanicista entre las moléculas de señalización y las propiedades físicas del tejido en desarrollo.
  • Los hallazgos ofrecen información sobre los principios más amplios de la morfogénesis.