Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.3K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.3K
GPCR Desensitization01:12

GPCR Desensitization

6.1K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.1K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

12.4K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
12.4K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

5.6K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.6K
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

7.2K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
7.2K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

413
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
413

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum.

Science (New York, N.Y.)·2025
Same author

Roles of the zona pellucida in gamete fusion and of the perivitelline space in blocking polyspermy in mice.

EMBO reports·2025
Same author

GABA <sub>A</sub> receptor gating imaged on the millisecond timescale.

bioRxiv : the preprint server for biology·2025
Same author

Protein Target Highlights in CASP16: Insights From the Structure Providers.

Proteins·2025
Same author

Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites.

The EMBO journal·2025

Video Experimental Relacionado

Updated: Jul 9, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

17.4K

GluD1 se une al GABA y controla la plasticidad inhibidora

Laura Piot1, Christina Heroven2, Simon Bossi1

  • 1Institut de Biologie de l'ENS (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, F-75005 Paris, France.

Science (New York, N.Y.)
|December 7, 2023
PubMed
Resumen

El receptor GluD1, un receptor ionotrópico del glutamato, se une al GABA y mejora la neurotransmisión inhibitoria en el hipocampo. Este hallazgo desafía la visión tradicional de distintas funciones de los receptores glutamatérgicos y GABAérgicos.

Más Videos Relacionados

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

13.7K
Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
07:32

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices

Published on: October 12, 2017

9.4K

Videos de Experimentos Relacionados

Last Updated: Jul 9, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

17.4K
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

13.7K
Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
07:32

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices

Published on: October 12, 2017

9.4K

Área de la Ciencia:

  • La neurociencia
  • Plasticidad sináptica
  • Biología molecular

Sus antecedentes:

  • La transmisión sináptica rápida se basa en los receptores ionotrópicos de glutamato (iGluR) para la excitación y los GABAAR para la inhibición.
  • El miembro de la familia iGluR GluD1 se encuentra tanto en las sinapsis excitatorias como en las inhibidoras, pero su papel en la inhibición es desconocido.

Objetivo del estudio:

  • Para investigar la función del receptor GluD1 en la neurotransmisión inhibitoria.
  • Para determinar si la activación de GluD1 afecta la señalización GABAérgica.

Principales métodos:

  • Análisis bioquímicos
  • Análisis estructurales
  • Análisis funcionales
  • Electrofisiología en el hipocampo de ratón adulto

Principales resultados:

  • GluD1 se une al GABA, una nueva función para los iGluR.
  • La activación de GluD1 aumenta las corrientes sinápticas GABAérgicas a través de un mecanismo no ionotrópico.
  • Esta mejora depende del anclaje trans-sináptico.

Conclusiones:

  • GluD1 actúa como un receptor GABA, modulando la plasticidad sináptica inhibidora.
  • Este descubrimiento desafía la separación clásica de las funciones de los receptores glutamatérgicos y GABAérgicos.