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La glia transmite información de valencia negativa durante el aprendizaje aversivo en Drosophila
Tomoyuki Miyashita1, Kanako Murakami1,2, Emi Kikuchi1
1Learning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Science (New York, N.Y.)
|December 21, 2023
Resumen
La glia envolvente (EG) transmite información aversiva en Drosophila mediante la liberación de glutamato a los cuerpos de las setas (MB). Esta liberación de glutamato es crucial para el aprendizaje asociativo y para prevenir asociaciones incorrectas durante el acondicionamiento.
Área de la Ciencia:
- La neurociencia
- Biología Glial
- El comportamiento de los animales
Sus antecedentes:
- El acondicionamiento olfativo aversivo en Drosophila requiere la transmisión de información de choque a los cuerpos de hongos (MB).
- Los mecanismos celulares precisos para transmitir esta valencia aversiva aún no se comprenden por completo.
Objetivo del estudio:
- Investigar el papel de la glia envolvente (EG) en la transmisión de información aversiva durante el aprendizaje olfativo de Drosophila.
- Elucidar los mecanismos moleculares por los cuales la EG contribuye al aprendizaje asociativo.
Principales métodos:
- Se utilizaron modelos de Drosophila para estudiar el condicionamiento olfativo aversivo.
- Exocitosis vesicular manipulada en la glia de revestimiento (EG).
- Se evaluó el impacto de la activación de EG y la señalización de glutamato en el aprendizaje y la memoria.
Principales resultados:
- El choque induce la exocitosis de glutamato vesicular desde la glia de revestimiento (EG) que rodea los MB.
- El bloqueo de la exocitosis EG perjudica el aprendizaje aversivo; la activación de la EG puede sustituir a los estímulos aversivos.
- El glutamato de EG se une a los receptores NMDA en los MB, lo que permite la afluencia de Ca2+ durante la exposición al olor.
- La exocitosis EG también desencadena la liberación de dopamina, evitando asociaciones inadecuadas.
Conclusiones:
- Las glia envolventes (EG) son críticas para transmitir información de valencia negativa a través de la liberación vesicular de glutamato.
- Este mecanismo es esencial para el aprendizaje asociativo en el sistema olfativo de Drosophila.
- La EG desempeña un papel multifacético en el aprendizaje al señalar la valencia aversiva y modular la liberación de dopamina.
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