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Las formas de reacción azida-alquina-tiol catalizadas por Cu son un antecedente ubicuo en los estudios proteómicos

Andreas Wiest1, Pavel Kielkowski1

  • 1Department of Chemistry, LMU Munich, Würmtalstr. 201, 81375 Munich, Germany.

Journal of the American Chemical Society
|January 12, 2024
PubMed
Resumen

La química de clic catalizada por cobre forma tiotriazoles no deseados con proteínas, lo que lleva a falsos positivos en la investigación. Los nuevos métodos minimizan este subproducto para obtener resultados más claros en el etiquetado bioortogonal.

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