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Desregulación persistente del complemento con signos de tromboinflamación en el COVID largo activo
Carlo Cervia-Hasler1, Sarah C Brüningk2,3, Tobias Hoch1
1Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Science (New York, N.Y.)
|January 18, 2024
Resumen
El Covid largo implica una desregulación del sistema inmunológico, particularmente el sistema del complemento. Este estudio identifica las proteínas complementarias y tromboinflamatorias como biomarcadores clave para el diagnóstico y el tratamiento de Long Covid.
Área de la Ciencia:
- Inmunología
- Proteomía
- Enfermedades infecciosas
Sus antecedentes:
- El Covid largo es una condición compleja y debilitante con una causa incierta.
- Comprender los mecanismos biológicos subyacentes es crucial para desarrollar tratamientos efectivos.
Objetivo del estudio:
- Para investigar los mecanismos moleculares de Long Covid utilizando la proteómica multimodal.
- Identificar biomarcadores potenciales para el diagnóstico y los objetivos terapéuticos de Long Covid.
Principales métodos:
- Análisis proteómico longitudinal del suero sanguíneo de 268 pacientes con COVID-19 hasta 12 meses después de la infección.
- Análisis de más de 6500 proteínas para identificar las diferencias entre Long Covid y los individuos recuperados.
- Aprendizaje automático aplicado para identificar los principales biomarcadores de proteínas.
Principales resultados:
- El Covid largo se caracteriza por la activación desregulada del sistema de complemento, incluidas las vías terminales, alternativas y clásicas.
- Se observó un aumento de los marcadores de hemólisis, daño tisular, activación plaquetaria y agregados monocito-plaquetarios.
- Los títulos de anticuerpos contra los virus del herpes se correlacionan con la activación clásica de la vía del complemento.
Conclusiones:
- El sistema del complemento y la tromboinflamación son fundamentales para la patogénesis del Long Covid.
- Las proteínas complementarias y tromboinflamatorias son prometedoras como biomarcadores diagnósticos y terapéuticos para el Long Covid.
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