Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Immunological Memory01:23

Immunological Memory

616
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
616
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

789
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
789
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

455
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
455
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

941
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
941

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Modulation of the bone marrow microenvironment by acute B-cell lymphoblastic leukemia-derived large oncosomes.

Blood advances·2026
Same author

Blood DNA Methylation Patterns Across Carotid, Coronary, and Peripheral Atherosclerosis: A Comparative Analysis in 2 Prospective Cohorts.

Journal of the American College of Cardiology·2026
Same author

Chronic Erythrocyte NO Production Accelerates Atherosclerosis by Increasing SMC De Novo Lipogenesis.

Circulation research·2026
Same author

Epithelial TMPRSS2 impairs glucose homeostasis in obese mice by regulating ghrelin-GLP-1 receptor signaling pathway.

JCI insight·2026
Same author

Protease-activated receptor 4 deficiency increases mortality, intracranial bleeding, and blood-brain barrier impairment following traumatic brain injury in mice.

Research and practice in thrombosis and haemostasis·2025
Same author

Simvastatin competitively inhibits cellular signaling of lipid-binding antiphospholipid antibodies.

Journal of thrombosis and haemostasis : JTH·2025

Video Experimental Relacionado

Updated: Jul 5, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.1K

Daño inmunológico en el covid largo

Wolfram Ruf1,2

  • 1Center for Thrombosis and Hemostasis, Johannes-Gutenberg- University Medical Center Mainz, Mainz, Germany.

Science (New York, N.Y.)
|January 18, 2024
PubMed
Resumen

Investigar las conexiones entre los sistemas de complemento y coagulación puede desbloquear nuevas estrategias terapéuticas para el Long Covid. Comprender estos vínculos es clave para desarrollar tratamientos efectivos para los síntomas posvirales persistentes.

Área de la Ciencia:

  • Inmunología y Hematología
  • Fisiopatología de las enfermedades infecciosas

Sus antecedentes:

  • El Covid largo, un síndrome post-viral complejo, presenta síntomas diversos y persistentes.
  • El sistema del complemento (parte de la inmunidad innata) y el sistema de coagulación (coagulación de la sangre) son cruciales para la defensa del huésped y la reparación de los tejidos.
  • La desregulación en estos sistemas se ha implicado en varias condiciones inflamatorias y trombóticas.

Objetivo del estudio:

  • Para explorar la intrincada interconexión entre el complemento y las cascadas de coagulación.
  • Investigar el papel potencial de las interacciones de coagulación del complemento en la fisiopatología de Long Covid.
  • Identificar objetivos terapéuticos potenciales dentro de estos sistemas interconectados para el tratamiento de Long Covid.

Principales métodos:

Más Videos Relacionados

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.3K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.3K

Videos de Experimentos Relacionados

Last Updated: Jul 5, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.1K
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.3K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.3K
  • Revisión de la literatura existente sobre las interacciones del complemento y la coagulación.
  • Análisis de los datos preclínicos y clínicos que relacionan las vías inmunológicas y de coagulación.
  • Exploración de los mecanismos moleculares subyacentes a la activación del complemento y su efecto en la coagulación.

Principales resultados:

  • La evidencia sugiere una activación cruzada significativa entre las vías del complemento y la coagulación.
  • La activación aberrante de estos sistemas puede contribuir a la trombosis microvascular y la inflamación observadas en el Long Covid.
  • Los componentes específicos del complemento y los factores de coagulación muestran potencial como biomarcadores y objetivos terapéuticos.

Conclusiones:

  • La interacción entre los sistemas de complemento y coagulación es un área prometedora para la investigación de Long Covid.
  • La orientación de este cruce podría ofrecer nuevas vías terapéuticas para el manejo de los síntomas de Long Covid.
  • Se requieren más investigaciones para trasladar estos hallazgos a la práctica clínica.