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Allergic Reactions02:06

Allergic Reactions

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Other Factors Affecting Respiration Centers01:17

Other Factors Affecting Respiration Centers

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Breathing is primarily an involuntary activity regulated by the brainstem respiratory centers. However, it can also be consciously controlled, allowing us to hold our breath or take deeper breaths when needed. This voluntary control is facilitated by the cerebral motor cortex, which bypasses the medullary centers to stimulate the respiratory muscles directly.
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical...
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Exon Recombination02:32

Exon Recombination

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
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Video Experimental Relacionado

Updated: Jul 5, 2025

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

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El estornudo por el SARS-CoV-2 explicado

Mitch Leslie

    Science (New York, N.Y.)
    |January 25, 2024
    PubMed
    Resumen

    Una proteína viral estimula las células nerviosas, lo que sugiere que podría ser un objetivo para futuros tratamientos. Este descubrimiento ofrece nuevas vías para intervenciones terapéuticas en enfermedades neurológicas.

    Área de la Ciencia:

    • La neurociencia
    • Virología
    • Biología molecular

    Sus antecedentes:

    • Las infecciones virales pueden afectar la función neurológica.
    • Comprender las interacciones entre el virus y el huésped es crucial para desarrollar tratamientos.

    Objetivo del estudio:

    • Para investigar el efecto de una proteína viral específica en las células nerviosas.
    • Para determinar si esta proteína viral podría servir como objetivo terapéutico.

    Principales métodos:

    • Se utilizan cultivos celulares de células nerviosas.
    • Las células nerviosas expuestas a la proteína viral.
    • Monitoreo de las respuestas y la actividad celular.

    Principales resultados:

    • Se encontró que la proteína viral estimula la actividad de las células nerviosas.

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  • Se observaron cambios significativos en las vías de señalización neuronal.
  • Conclusiones:

    • La proteína viral estudiada tiene un impacto directo en la función de las células nerviosas.
    • Esta proteína viral representa un objetivo potencial para nuevas estrategias terapéuticas.