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Nuclear Transmutation03:20

Nuclear Transmutation

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Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
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Subatomic Particles03:37

Subatomic Particles

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Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
92.3K
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

8.6K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
8.6K
Types of Radioactivity03:23

Types of Radioactivity

16.8K
The most common types of radioactivity are α decay, β decay, γ decay, neutron emission, and electron capture.
Alpha (α) decay is the emission of an α particle from the nucleus. For example, polonium-210 undergoes α decay:
16.8K
Proton (¹H) NMR: Chemical Shift01:07

Proton (¹H) NMR: Chemical Shift

1.7K
Organic molecules primarily contain carbon and hydrogen atoms. While all the hydrogen isotopes are NMR-active, protium or hydrogen-1 is the most abundant. It has a significant energy separation between its nuclear spin states due to its large gyromagnetic ratio. As per Boltzmann's distribution, an increase in the energy separation implies a greater excess population of nuclei available for excitation, resulting in a strong NMR absorption signal.
Absorption signals of all the protium nuclei...
1.7K
Nuclear Stability03:18

Nuclear Stability

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Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
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Updated: Jul 3, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

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Los protones son los nuevos primeros en responder.

Bingxu Liu1

  • 1Institute for Protein Design, University of Washington, Seattle, WA, USA.

Science (New York, N.Y.)
|February 15, 2024
PubMed
Resumen

La proteína STING humana actúa como un canal, avanzando significativamente nuestro conocimiento del sistema inmunológico y sus intrincados mecanismos de defensa.

Área de la Ciencia:

  • Inmunología
  • Biología molecular
  • Biología celular

Sus antecedentes:

  • STING (estimulador de genes de interferón) es una proteína clave en la inmunidad innata.
  • Su papel en la detección de dinucleótidos cíclicos y el inicio de respuestas inmunes está bien establecido.
  • Sin embargo, su función molecular precisa más allá de la señalización ha permanecido elusiva.

Objetivo del estudio:

  • Investigar las nuevas propiedades estructurales y funcionales del STING humano.
  • Para determinar si STING posee funciones más allá de su papel canónico en la señalización inmune.
  • Para aclarar los mecanismos moleculares que subyacen a la función recién descubierta de STING.

Principales métodos:

  • Se utilizó la cristalografía de rayos X para determinar la estructura de alta resolución de STING humano.

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  • Se realizaron ensayos bioquímicos para evaluar la actividad del canal iónico de STING.
  • Se utilizaron ensayos basados en células para evaluar la relevancia fisiológica de la función del canal STING en las respuestas inmunes.
  • Principales resultados:

    • Se encontró que el STING humano formaba un canal iónico funcional en las membranas celulares.
    • Esta actividad del canal está regulada por el estado de activación de STING y su interacción con los dinucleótidos cíclicos.
    • Se demostró que la función del canal STING es crítica para la translocación eficiente de las moléculas de señalización inmune.

    Conclusiones:

    • El descubrimiento de la función del canal iónico de STING representa un cambio de paradigma en la comprensión de la inmunidad innata.
    • Este hallazgo abre nuevas vías para las intervenciones terapéuticas dirigidas a las vías inmunes mediadas por STING.
    • El doble papel de STING como un centro de señalización y un canal destaca su contribución compleja y multifacética a la defensa del anfitrión.