Video Experimental Relacionado

Updated: Jul 2, 2025

Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking
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Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking

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Mecanismos estructurales de la modulación y activación alosterica del receptor nicotínico α7

Sean M Burke1, Mariia Avstrikova2, Colleen M Noviello3

  • 1Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|February 21, 2024
PubMed
Resumen

Las estructuras de alta resolución revelan cómo los moduladores alostéricos positivos interactúan con el receptor de acetilcolina nicotínica alfa7 (α7 nAChR). Las diferencias en los mecanismos de apertura de canales explican las diferentes actividades del modulador, que ofrecen información terapéutica.

Palabras clave:
Crio-EMelectrofisiologíaCanal iónico ligado por ligandoDinámica molecularreceptores de los neurotransmisoresReceptor de la acetilcolina nicotínicaModulador alostérico positivoBiología estructuralDiseño de fármacos guiado por la estructura

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